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Studies have found that GLP-1 mimetics can cross the blood-brain barrier and have neuroprotective effects, including reducing oxidative stress and chronic inflammatory responses in the brain

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Similarly, cleavage at four conjugated sites (Pro342-Thr343, Thr343-Pro344, Pro344-Arg345 and Arg345-Lys346) was detected in vivo for the active domain of jr PPO1 purified from leaves 34